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The vivacious actress played the title role in some of the most memorable romantic comedies of the 1980s and 1990s, 

including the Nora Ephron classics "When Harry Met Sally," "You've Got Mail," and "Sleepless in Seattle," as well as more unusual films like "Joe Versus the Volcano.

With the movie "What Happens Later," in which the 61-year-old actress co-stars with the 63-year-old David Duchovny

she is once again in her favorite genre. The story revolves around a former couple as they work out their differences

detained at an airport, making it one of the rare romantic comedies to include two sexagenarians

Her comeback was enthusiastically welcomed by movie lovers on X (previously Twitter)

when the trailer for "What Happens Later" (out in theaters on October 13) debuted on Wednesday